Total Pageviews

Friday, October 23, 2026

Potential for mRNA technology

 

 

 mRNA technology extends far beyond COVID-19 vaccines and is being developed for cancer immunotherapy, protein replacement, infectious disease prevention, and gene editing. [1]

 

 

Cancer Immunotherapy
  • Personalized Cancer Vaccines: Scientists analyze a patient's tumor to create custom mRNA sequences that instruct the immune system to recognize and attack specific tumor neoantigens (unique proteins on cancer cells). Late-stage clinical trials have shown strong results for melanoma (such as Moderna and Merck’s mRNA-4157 combined with Keytruda), as well as trials targeting lung, kidney, bladder, and pancreatic cancers. [1, 2, 3, 4]
  •  
  •  
    Infectious Disease Prevention
    • Universal Influenza and RSV: Researchers are building fast-adapting multivalent mRNA vaccines for seasonal flu and respiratory syncytial virus (RSV) to bypass slow egg-based manufacturing. Other Viruses: Clinical and pre-clinical pipelines target complex pathogens such as HIV, Zika, Ebola, Nipah, cytomegalovirus (CMV), and malaria. [1, 2]
    •  
    •  
    •  
      Protein Replacement & Genetic Disorders
      • Missing Protein Production: Synthetic mRNA can enter cells and instruct ribosomes to manufacture functional proteins that a patient's body fails to produce naturally. [1, 2]  Target Conditions: This approach is being explored for rare and chronic genetic conditions like cystic fibrosis, hemophilia, and muscular dystrophy. [1] Gene Silencing and Editing: mRNA can deliver gene-editing tools—such as CRISPR-Cas components or instructions to silence harmful liver genes (like KLKB1 for hereditary angioedema or transthyretin for ATTR amyloidosis). [1, 2, 3]
      •  
      •  
      •  
    •  
      Autoimmune Diseases & Cardiovascular Care
      • Immune Tolerance: For autoimmune conditions like multiple sclerosis or rheumatoid arthritis, experimental mRNA is designed to calm an overactive immune response rather than trigger it.  
      • Cardiovascular Disease: Early-stage studies are testing mRNA therapies to reduce vascular inflammation, stabilize atherosclerotic plaques, or prompt heart muscle repair following a heart attack.
    •  
    •  
    •  
    •  
    •  

Monday, October 19, 2026

Vaccination

 This blog is word for word copy from an article in the 7March2026 copy of New Scientist on Page 20.  It details some surprising side benefits of vaccinations.  If it could be summarized in one sentence, it would seem that a vaccination causes a general gingering up of the whole immune system which, as you will read, has some beneficial effects.  The article is written by a New Scientist writer, Michael Le Page.


Heading

The surprising vaccine side effects that boost long-term health.  People often focus on the bad side effects of vaccines, but they can have some great ones too.


I am currently arranging to get a shingles Vaccination.  I had shingles at university and still bear the scars. so I really don't want to risk getting it again.  But I also have in mind the fact that the benefits of the shingles vaccine aren't limited to preventing shingles.  And this isn't unusual.  Many vaccines have benefits that go way beyond protecting against single virus of bacterium - fact that aren't nearly as widely know as they should be.

 

Let's start with shingles.  A study of more than a million people last year reported that those given the Zostavax shingles vaccine were 26% less likely to die from heart disease or experience a stroke, heart attack or heart failure during an average of 6 years after the shot - a massive reduction in the risk for such an easy intervention.

 

What's more, people given a newer shingles vaccine called Shingrix were 17% less likely to develop dementia in the next 6 years, compared with those given Zostavax.  Since, several studies have shown that Zostavax also reduces the risk of dementia, the overall reduction in risk with Shingrix should be even larger.

 

Flue vaccines also have cardiovascular benefits.  For instance, and analysis combining data from more than 9000 people involved in 6 trials found those vaccinated against flu had a 34% lower risk of a heat attack or stroke in the next year.  The benefit was even greater for people with a recent history of heart problems.

 

The new vaccines for respiratory syncytial virus or RSV, seem to help prevent heart problems too.  A study involving around 130,000 people over [age] 60 found that those who had one kind of RSV vaccine were less likely to be hospitalized with heart or lung issues than those who went unvaccinated.

 

Then there are the covid-19 mRNA vaccines.  They turn out to boost the immune response to tumors along with Immunotherapy, extending peoples lives

 

I could keep listing examples, but let's turn instead to why so many vaccines have these wider benefits.  We don't know the precise mechanism but it's not surprising that they do.

 

Viruses can do lasting physical damage to the body and the immune response to them can also harm tissues.  So-called cytokine storms, in which the body overreacts and releases too many immune stimulating signals, are often what kill people with infections such as flu or covid-19

 

Many viruses also target our immune system to help evade it, weakening our defenses.

 

There's this idea in some circles that natural immunity from getting a disease is better than vaccination.  It's bonkers for all the reasons above and more, and measles is a great example of why.

 

Measles vaccines have cut the number of deaths from the disease from more than 2 million a year before 1980 to fewer than 100,000 in 2024.  They have also had the unexpected effect of reducing the number of children dying from other infectious diseases.

 

Why?  Part of the answer is that measles kills off some immune cells, leaving children more vulnerable to a wide range of infections for years afterwards.  But measles vaccines also seem to train the immune system in a way that boosts its wider effectiveness.  This training effect is so beneficial, it's even been suggested we should keep giving children the measles vaccine even if measles is eliminated.

 

It would be too good to be true if all vaccines trained our immune system in this way.  There is evidence a few vaccines have the opposite effect.  But this doesn't mean they don't still save lives.

 

The key question is whether you are better off getting vaccinated than not.  All too often the focus is entirely on very rare or entirely imaginary adverse effects of vaccines instead of on the risks of infections or the wider benefits of the vaccine.

 

I have no doubts that will make me better off.  I'll be getting my shingles vaccine and a flu jab every year and the RSV vaccine when it's offered , at the very least.


23

Wednesday, October 7, 2026

To all Republicans, sane and not so sane.

This is a direct copy of an article on FB by Christina Lorey.  Good on you Christina.  I couldn't have said it better.  Criminals like Trump will arise in all societies.  The measure of a society is how you stop their actions and restore sanity to your society.  America has failed miserably in this and it is the responsibility of Representatives and Senators of the Republican party who have the majority in all four branches of government.  (Supreme Court, Presidency, House of Representives, Senate).  The rule of law is, and has been for many years, a joke in America.  Trump is just the latest and most extreme example and it has exposed that America is a failed society.

 

From Christina Lorey, on FB:

A message to all sane Republicans:

He pardoned 1,600 violent criminals.
You said nothing.

He bulldozed the East Wing.
You said nothing.

He interfered with the release of the Epstein files. You said nothing.

He took over the Kennedy Center and renamed it after himself. You said nothing.

He accepted a $400 million airplane as a personal gift. You said nothing.

He threatened Canada, Cuba, Denmark, Greenland, Venezuela, Colombia, and Brazil. You said nothing.

He tariffed just about everyone but Russia, causing inflation and instability worldwide. You said nothing.

He attacked a nation during mediated negotiations. You said nothing.

His ill-conceived war killed 175 children on day one. You said nothing.

He alienated and insulted our allies. You said nothing.

His ICE Army terrorized and murdered U.S. citizens. You said nothing.

He committed murder on the high seas. You said nothing.

He co-opted the Justice Department and directed it to prosecute his political enemies. You said nothing.

It’s time to start talking.