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Friday, October 23, 2026

Potential for mRNA technology

 

 

 mRNA technology extends far beyond COVID-19 vaccines and is being developed for cancer immunotherapy, protein replacement, infectious disease prevention, and gene editing. [1]

 

 

Cancer Immunotherapy
  • Personalized Cancer Vaccines: Scientists analyze a patient's tumor to create custom mRNA sequences that instruct the immune system to recognize and attack specific tumor neoantigens (unique proteins on cancer cells). Late-stage clinical trials have shown strong results for melanoma (such as Moderna and Merck’s mRNA-4157 combined with Keytruda), as well as trials targeting lung, kidney, bladder, and pancreatic cancers. [1, 2, 3, 4]
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    Infectious Disease Prevention
    • Universal Influenza and RSV: Researchers are building fast-adapting multivalent mRNA vaccines for seasonal flu and respiratory syncytial virus (RSV) to bypass slow egg-based manufacturing. Other Viruses: Clinical and pre-clinical pipelines target complex pathogens such as HIV, Zika, Ebola, Nipah, cytomegalovirus (CMV), and malaria. [1, 2]
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      Protein Replacement & Genetic Disorders
      • Missing Protein Production: Synthetic mRNA can enter cells and instruct ribosomes to manufacture functional proteins that a patient's body fails to produce naturally. [1, 2]  Target Conditions: This approach is being explored for rare and chronic genetic conditions like cystic fibrosis, hemophilia, and muscular dystrophy. [1] Gene Silencing and Editing: mRNA can deliver gene-editing tools—such as CRISPR-Cas components or instructions to silence harmful liver genes (like KLKB1 for hereditary angioedema or transthyretin for ATTR amyloidosis). [1, 2, 3]
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      Autoimmune Diseases & Cardiovascular Care
      • Immune Tolerance: For autoimmune conditions like multiple sclerosis or rheumatoid arthritis, experimental mRNA is designed to calm an overactive immune response rather than trigger it.  
      • Cardiovascular Disease: Early-stage studies are testing mRNA therapies to reduce vascular inflammation, stabilize atherosclerotic plaques, or prompt heart muscle repair following a heart attack.
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Monday, October 19, 2026

Vaccination

 This blog is word for word copy from an article in the 7March2026 copy of New Scientist on Page 20.  It details some surprising side benefits of vaccinations.  If it could be summarized in one sentence, it would seem that a vaccination causes a general gingering up of the whole immune system which, as you will read, has some beneficial effects.  The article is written by a New Scientist writer, Michael Le Page.


Heading

The surprising vaccine side effects that boost long-term health.  People often focus on the bad side effects of vaccines, but they can have some great ones too.


I am currently arranging to get a shingles Vaccination.  I had shingles at university and still bear the scars. so I really don't want to risk getting it again.  But I also have in mind the fact that the benefits of the shingles vaccine aren't limited to preventing shingles.  And this isn't unusual.  Many vaccines have benefits that go way beyond protecting against single virus of bacterium - fact that aren't nearly as widely know as they should be.

 

Let's start with shingles.  A study of more than a million people last year reported that those given the Zostavax shingles vaccine were 26% less likely to die from heart disease or experience a stroke, heart attack or heart failure during an average of 6 years after the shot - a massive reduction in the risk for such an easy intervention.

 

What's more, people given a newer shingles vaccine called Shingrix were 17% less likely to develop dementia in the next 6 years, compared with those given Zostavax.  Since, several studies have shown that Zostavax also reduces the risk of dementia, the overall reduction in risk with Shingrix should be even larger.

 

Flue vaccines also have cardiovascular benefits.  For instance, and analysis combining data from more than 9000 people involved in 6 trials found those vaccinated against flu had a 34% lower risk of a heat attack or stroke in the next year.  The benefit was even greater for people with a recent history of heart problems.

 

The new vaccines for respiratory syncytial virus or RSV, seem to help prevent heart problems too.  A study involving around 130,000 people over [age] 60 found that those who had one kind of RSV vaccine were less likely to be hospitalized with heart or lung issues than those who went unvaccinated.

 

Then there are the covid-19 mRNA vaccines.  They turn out to boost the immune response to tumors along with Immunotherapy, extending peoples lives

 

I could keep listing examples, but let's turn instead to why so many vaccines have these wider benefits.  We don't know the precise mechanism but it's not surprising that they do.

 

Viruses can do lasting physical damage to the body and the immune response to them can also harm tissues.  So-called cytokine storms, in which the body overreacts and releases too many immune stimulating signals, are often what kill people with infections such as flu or covid-19

 

Many viruses also target our immune system to help evade it, weakening our defenses.

 

There's this idea in some circles that natural immunity from getting a disease is better than vaccination.  It's bonkers for all the reasons above and more, and measles is a great example of why.

 

Measles vaccines have cut the number of deaths from the disease from more than 2 million a year before 1980 to fewer than 100,000 in 2024.  They have also had the unexpected effect of reducing the number of children dying from other infectious diseases.

 

Why?  Part of the answer is that measles kills off some immune cells, leaving children more vulnerable to a wide range of infections for years afterwards.  But measles vaccines also seem to train the immune system in a way that boosts its wider effectiveness.  This training effect is so beneficial, it's even been suggested we should keep giving children the measles vaccine even if measles is eliminated.

 

It would be too good to be true if all vaccines trained our immune system in this way.  There is evidence a few vaccines have the opposite effect.  But this doesn't mean they don't still save lives.

 

The key question is whether you are better off getting vaccinated than not.  All too often the focus is entirely on very rare or entirely imaginary adverse effects of vaccines instead of on the risks of infections or the wider benefits of the vaccine.

 

I have no doubts that will make me better off.  I'll be getting my shingles vaccine and a flu jab every year and the RSV vaccine when it's offered , at the very least.


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Wednesday, October 7, 2026

To all Republicans, sane and not so sane.

This is a direct copy of an article on FB by Christina Lorey.  Good on you Christina.  I couldn't have said it better.  Criminals like Trump will arise in all societies.  The measure of a society is how you stop their actions and restore sanity to your society.  America has failed miserably in this and it is the responsibility of Representatives and Senators of the Republican party who have the majority in all four branches of government.  (Supreme Court, Presidency, House of Representives, Senate).  The rule of law is, and has been for many years, a joke in America.  Trump is just the latest and most extreme example and it has exposed that America is a failed society.

 

From Christina Lorey, on FB:

A message to all sane Republicans:

He pardoned 1,600 violent criminals.
You said nothing.

He bulldozed the East Wing.
You said nothing.

He interfered with the release of the Epstein files. You said nothing.

He took over the Kennedy Center and renamed it after himself. You said nothing.

He accepted a $400 million airplane as a personal gift. You said nothing.

He threatened Canada, Cuba, Denmark, Greenland, Venezuela, Colombia, and Brazil. You said nothing.

He tariffed just about everyone but Russia, causing inflation and instability worldwide. You said nothing.

He attacked a nation during mediated negotiations. You said nothing.

His ill-conceived war killed 175 children on day one. You said nothing.

He alienated and insulted our allies. You said nothing.

His ICE Army terrorized and murdered U.S. citizens. You said nothing.

He committed murder on the high seas. You said nothing.

He co-opted the Justice Department and directed it to prosecute his political enemies. You said nothing.

It’s time to start talking.

Sunday, September 13, 2026

How to build a beaver deceiver

So why would you want to build a Beaver Deceiver.  Beavers build dams.  Dams make ponds.   This can result in the flooding of something you don't want flooded or can wash away of a piece of road if they dam up a culvert.  If you go the 'human way' and kill or remove the   beavers, you will have a life time job.   Do the job right and build a beaver deceiver and you have solved the problem  You can now benefit from all the myriad  benefits that beaver ponds create.


So how do you build a simple beaver deceiver when your only aim is to limit the level of  the water in a beaver pond (ie - not to protect a culvert).  You start by getting a piece of that black corrugated pipe of a suitable diameter (big enough to take care of the flow of the stream during the spring melt).  It must be long enough to go from the deepest part of the pond, usually found a couple of meters upstream of the dam and to extend a little beyond the dam.  To install it, you cut away a little material in the middle of the top of the beaver dam and lay the pipe in this notch.  Pound a couple of wooden stakes into the top of the dam, one on either side of the pipe and connect them with a board or similar which rests on top of the pipe.  This board will hold the pipe down while the beavers  repair the damage that night that you have done.







Now as shown in the diagram above, you must build some sort of a cage for the inflow end of the pipe.  It should have a mesh lid on it an set so that the top of the cage is below the water level.  In fact it is best if it is below the level that ice or any other floating object will reach.  The wire mesh that is used to reinforce concrete slabs is a good choice and myself, I prefer a round design rather than the rectangular one shown.  Cut off the cross (horizontal) bars from the bottom of the mesh so that the cage can be pounded into the bottom of the pond.


So how about protecting a culvert.  Proceed as above but make sure that the pipe is long enough to extend into the culvert.  Construct a cage over the rest of the culvert.  One more thing and you are finished.  You are in danger of siphoning down the pond and you don't want that.  Beaver pond complexes are a great tourist attraction besides all the good that they do.  Take a hole saw on a battery drill and make a few holes on the top of the pipe where the pipe leaves the dam plus a couple more.  This will break the siphon.




Monday, September 7, 2026

Did climate change wipe out the mega-fauna


Around the time of the transition ~12,000 years ago, between a world with continental glaciers as much as 3km deep, extending, in North America to below the USA-Canadian border, and our present more benign climate, mega-fauna disappeared from  the Americas.  So was this due to the change in the climate as we left, what is popularly called an Ice Age to our present warmer climate.  First we have to establish some terms and a little background.


Over the past 2.75m (million) years, the world has gone through about 40 cycles of Continental glaciers and warmer periods, such as we are living in at present.  During the first half of this 2.75m year period, the cycles were about 41k (thousand) years while over the past half of this two and three quarter million year Ice Age, cycles have been about 100k years.  The exact timelines are hard to establish on the land, because each cold period, when kilometer-thick glaciers grind across the landscape, they wipe out the record of previous glacial an interglacial periods.


All information was not lost, though.   Ice itself is one path to documenting past fluctuations.  The Antarctic has been glaciated for at least 34m years and the ice is built up in layers which are much like tree rings.  Generally (not always) one layer is laid down per year*.  Glaciation has fluctuated but there is a reliable, continuous record over at least 800,000 years.   In addition there are ocean bottom sediments and a peculiar meteor crater in Northern Siberia called El'Gy'Gytgyn that has a sediment record which extends over 3.6m years.

*Sometimes a layer is not laid down in a given year and a warm period can wipe out a number of layers. A unseasonable warm period in the middle of a year can result in two rings for a year.  But there are work-arounds for these problems.


As mentioned something interesting,  has been observed from these records.  It is that for the first half of this 2.75m year period of alterations between icy and less icy times, the cycle length has been about 41k years while for the second half of this period, the cycle is closer to 100k years*.  Incidentally, the previous warm period goes by various names but the one that many 'westerners' use is the Eemian interglacial period.  The one we are in now is called the Holocene Interglacial Period.

*For some reason different Milankovitch Cycles dominated at the beginning of this 
Ice age than more recently.  Note that the Ice Age has not ended.  We are just in one of the interglacial periods and by now should have been,  sliding toward the next Glacial period (but are not).


The popular literature and even some scientists call the most recent glaciated period an Ice Age. Even in the above video this is so. I have no objection to this term (not much!!!) but if we use it to describe the recent glaciated period then we have to  use a different name for the 2.75m year period during which we have had  many alternations between warm and cold periods.  


So for the rest of this diatribe, I am going to call the last 2.75m year ice age, an Ice Age and will call glaciated periods 'Glacial Periods' and the warmer interglacial periods, 'Interglacial Periods'.  At present we are in the so called Holocene Interglacial Period and as mentioned, the previous one is called the Eemian Interglacial period*.

*Previous Interglacial Periods have different names but in order from the most recent to more ancient ones they are often called, Eemian, La Bouchet, Parfleet, Hoxnian, MI13, Cromerian, Holstein, Waalian, Bramertenian, Passtonian etc.  


Now we come to two problems if we want to insist on the theory that the transition from the recent Glaciated Period to the present Holocene Interglacial period caused the demise of the immensely varied mega-fauna of the Americas.  


I think everyone would agree that, based on our present knowledge of how long it takes to create a new species, that all this megafauna didn't evolve over the past 100k years.  To put it another way, the ancestors of the elephant types, Camel types, Giant ground sloths, Giant beavers, Equinine species and so forth existed at the start of the 2.75m Ice age that we are still in.  Undoubtedly they evolved special adaptations to glaciation over the glaciated periods of the 2.75m year ice age. For instance, greater harryness or thickness of blubber might have increased as we slid into an Glacial Period and decreased as we left a Glacial Period*.  

*If you think that evolution is always a very very slow process, look at how the Galapagos finches change their bill shape over El Nino, La Nina cycles as the food supply changes. Or for that matter look at the proliferation of Dinosaur types following the end-Triasic extinction of the existing reptiles when the Ecological niches suddenly were empty.


The critical point is that they didn't go extinct, during previous slides from a warm period into a cold period or from a cold period into a warm period.  And there were at least 40 such cycles.  So why would we think that the change in the climate, which happened many times before caused their demise only this time.  

In addition, the record from the previous 4 cycles, for which we have the best information, were very similar to the most recent one.  A great treatment of the past handful of glacial cycles is found in the book Plows Plagues and Petroleum by Ruddiman*

*Ruddiman makes a very convincing argument that man has been interfering with the climate for at least the past 8000 years and that the level of interference was just about enough to counter what should have been our next slide into  a glacial period.  Now we have too much of a good thing.



The second problem is the evidence from other continents.  The incredibly varied population of mega-Marsupials and Monotremes in Australia went extinct about  45k years ago, around the time that man arrived in Australia.  The amazingly varied mega-fauna of the Americas disappeared around 12k years ago, just as the first people spread through the Americas and the mega fauna of, of New Zealand, consisting of giant ground living birds, plus a giant eagle and many species of 'dickie birds' disappeared 700 years ago just as the first people arrived in New Zealand.  Coincidence??  I don't think so.


The only conclusion that seems reasonable to me is that in every case, the first people who arrived in a new land multiplied and ate their way through all the megafauna.  There are at least three reasons that many people find this conclusion is hard to accept.

Leaving aside the nutters who believe that the world is only ~6000 years old, It is very hard to grasp deep-time.  Even grasping the length of time back to the previous warm period, which is 62 time as long as from the time of Christ to the present, is hard.  Grasping the idea of millions of years is even more daunting.  

A secibd problem is our difficulty in accepting exponential growth.  It is hard to grasp how fast a small starter population of people can multiply in an environment when all those edible animals are completely unwary of people and all that energy rich meat is there for the taking.  Lets be really conservative and say that a population of humans can double each generation and a generation is 25 years.  I think you would agree that in the absence of birth control methods, this is ridiculously conservative.  Take a starter population of two and see how many individuals we would have in 20 generations (20 x 25 years = 500 years).  Raise 2 to the power of 20 and you get 1,048,576 people.  One more generation (25 years) and you have 2,097152 people.  One more and you have 4,194,304.  You see where this is going.  Exponential growth which only added a handful of people at the beginning each generation is now adding 2m people every generation.


Of course, a starter population would likely be a small tribe which for genetic reasons would be far more viable.


The further reason is PC (political correctness).  We have got so used to maintaining the legend that the first people, whether from the Americas, from Australia or from New Zealand are great ecologists and couldn't possibly be responsible for the demise of the mega fauna of their home range.  In fact they are just people like we are and find it hard to moderate their motivations for the greater long term good of themselves and their societies.  We Europeans have only recently realized what damage we have done to the environment and are far from catching up and modifying our actions to preserve what we have left.  Why do we think that an earlier population of humans would do any better when faced with unbelievable abundance.


 The third reason is hubris.  For some reason we see ourselves as more intelligent than our distant ancestors when recent findings show that this is, pretty clearly not the case.  They just applied their intelligence to different problems.  Just imagine how you would fair if transported back into a glacial period in Europe in a period in which Neanderthals and our ancestors survived and thrived.  

And fourth, we can't imagine that they were capable of killing such huge animals.  If you have this bias, just look at how the pigmies in the jungles kill jungle elephants or how the bushmen of the Kalahari, kill Kudu.


This leaves a contrary problem.  How did some of the mega-fauna of Africa survive until Europeans arrived on the continent.  After all this is where man evolve.  The only explanation I can think of is that the animals evolved a fear of man as man became more and more able to kill them and to kill them at greater and greater distances (first thrusting spears, then throwing spears, then the throwing sticks (atiatl) for throwing spears and then bow and arrow) not to forget the sling for throwing stones.  Animals would have learned that when the strange two legged animal was around, they kept getting hit by heavy and pointy objects. Thus the animals probably evolved avoiding behaviors as man became more and more able to kill them and to kill them at greater distances. A process just like the antelope learning to avoid predatory cats. 


Perhaps, as we Europeans apologize for the wrongs we did to the  ancestors of the first people, we should ask for an apology for the destruction of the mega-fauna at the hands of their ancestors.